iFSP1
CAS No. | 150651-39-1 | Cat. No. | BCP37001 |
Name | iFSP1 | ||
Synonyms | iFSP-1; iFSP 1; | ||
Formula | C20H13N5 | M. Wt | 323.36 |
Description | iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1) (AIFM2) with an EC50 of 103 nM. iFSP1 selectively induces ferroptosis in GPX4-knockout cells which overexpressed FSP1. iFSP1 is able to sensitize a variety of human cancer cell lines to the ferroptosis inducer, such as (1S,3R)-RSL3. | ||
Pathways | Apoptosis Pathway | ||
Targets | Ferroptosis |
Structure
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