iFSP1

  • Chemical Properties
CAS No. 150651-39-1 Cat. No. BCP37001
Name iFSP1
Synonyms iFSP-1; iFSP 1;
Formula C20H13N5 M. Wt 323.36
  • Biological Activity
Description iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1) (AIFM2) with an EC50 of 103 nM. iFSP1 selectively induces ferroptosis in GPX4-knockout cells which overexpressed FSP1. iFSP1 is able to sensitize a variety of human cancer cell lines to the ferroptosis inducer, such as (1S,3R)-RSL3.
Pathways Apoptosis Pathway 
Targets Ferroptosis 

Structure

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