iFSP1 New
Data Sheet
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| CAS No. | 150651-39-1 | Cat. No. | BCP37001 |
| Name | iFSP1 | ||
| Synonyms | iFSP-1; iFSP 1; | ||
| SMILES | CC1=CC=C(C=C1)C2=C(C3=NC4=CC=CC=C4N3C(=C2C#N)N)C#N | ||
| Chemical Name | |||
| Formula | C20H13N5 | M. Wt | 323.36 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1) (AIFM2) with an EC50 of 103 nM. iFSP1 selectively induces ferroptosis in GPX4-knockout cells which overexpressed FSP1. iFSP1 is able to sensitize a variety of human cancer cell lines to the ferroptosis inducer, such as (1S,3R)-RSL3. | ||
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