AZD-8529 mesylate

  • 化学数据
CAS号 1314217-69-0 货号 BCP37624
中文名 AZD-8529 mesylate
英文名 AZD-8529 mesylate
中文别名
英文别名 AZD8529 mesylate;AZD 8529 mesylate;
分子式 C25H28F3N5O6S 分子量 583.58
  • 用途
生物活性 AZD-8529 is a a positive allosteric modulator at the mGluR2 receptor. AZD8529 decreases Nicotine Self-Administration and Relapse in Squirrel Monkeys. AZD8529 potentiated agonist-induced activation of mGluR2 in the membrane-binding assay and in primate cortex, hippocampus, and striatum. In monkeys, AZD8529 decreased nicotine self-administration at doses (.3-3 mg/kg) that did not affect food self-administration. AZD8529 also reduced nicotine priming- and cue-induced reinstatement of nicotine seeking after extinction of the drug-reinforced responding. In rats, AZD8529 decreased nicotine-induced accumbens dopamine release. The positive allosteric modulators of metabotropic glutamate receptor 2 should be considered for relapse prevention.
信号通路 Neuro Signaling Pathway GPCR/G Protein 
靶 点 mGluR 

结构式

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