AZD-8529 mesylate 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP37624CAS号：1314217-69-0纯度：98%

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CAS号	1314217-69-0	货号	BCP37624
中文名	AZD-8529 mesylate
英文名	AZD-8529 mesylate
中文别名
英文别名	AZD8529 mesylate；AZD 8529 mesylate;
SMILES	CC1=CC(=CC2=C1C(=O)N(C2)CC3=CC=C(C=C3)OC(F)(F)F)C4=NC(=NO4)CN5CCNCC5.CS(=O)(=O)O
化学名称
分子式	C25H28F3N5O6S	分子量	583.58
纯度	98%	配送	惯例下常温包邮
产品描述	AZD-8529 is a a positive allosteric modulator at the mGluR2 receptor. AZD8529 decreases Nicotine Self-Administration and Relapse in Squirrel Monkeys. AZD8529 potentiated agonist-induced activation of mGluR2 in the membrane-binding assay and in primate cortex, hippocampus, and striatum. In monkeys, AZD8529 decreased nicotine self-administration at doses (.3-3 mg/kg) that did not affect food self-administration. AZD8529 also reduced nicotine priming- and cue-induced reinstatement of nicotine seeking after extinction of the drug-reinforced responding. In rats, AZD8529 decreased nicotine-induced accumbens dopamine release. The positive allosteric modulators of metabotropic glutamate receptor 2 should be considered for relapse prevention.