AZD-8529
| CAS No. | 1092453-15-0 | Cat. No. | BCP37625 |
| Name | AZD-8529 | ||
| Synonyms | AZD8529; AZD 8529; | ||
| Formula | C24H24F3N5O3 | M. Wt | 487.47 |
| Description | AZD-8529 is a a positive allosteric modulator at the mGluR2 receptor. AZD8529 decreases Nicotine Self-Administration and Relapse in Squirrel Monkeys. AZD8529 potentiated agonist-induced activation of mGluR2 in the membrane-binding assay and in primate cortex, hippocampus, and striatum. In monkeys, AZD8529 decreased nicotine self-administration at doses (.3-3 mg/kg) that did not affect food self-administration. AZD8529 also reduced nicotine priming- and cue-induced reinstatement of nicotine seeking after extinction of the drug-reinforced responding. In rats, AZD8529 decreased nicotine-induced accumbens dopamine release. The positive allosteric modulators of metabotropic glutamate receptor 2 should be considered for relapse prevention. | ||
| Pathways | Neuro Signaling Pathway GPCR/G Protein | ||
| Targets | mGluR | ||
Structure
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