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AZD-8529 Chemical Structure

AZD-8529

Data Sheet For research use only. Not for human use.
Cat. No. :BCP37625CAS No. :1092453-15-0Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1092453-15-0 Cat. No. BCP37625
Name AZD-8529
Synonyms AZD8529; AZD 8529;
SMILES CC1=CC(=CC2=C1C(=O)N(C2)CC3=CC=C(C=C3)OC(F)(F)F)C4=NC(=NO4)CN5CCNCC5
Chemical Name
Formula C24H24F3N5O3 M. Wt 487.47
Purity 98% Storage Store at 4-8°C
Description AZD-8529 is a a positive allosteric modulator at the mGluR2 receptor. AZD8529 decreases Nicotine Self-Administration and Relapse in Squirrel Monkeys. AZD8529 potentiated agonist-induced activation of mGluR2 in the membrane-binding assay and in primate cortex, hippocampus, and striatum. In monkeys, AZD8529 decreased nicotine self-administration at doses (.3-3 mg/kg) that did not affect food self-administration. AZD8529 also reduced nicotine priming- and cue-induced reinstatement of nicotine seeking after extinction of the drug-reinforced responding. In rats, AZD8529 decreased nicotine-induced accumbens dopamine release. The positive allosteric modulators of metabotropic glutamate receptor 2 should be considered for relapse prevention.
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