AZD-8529 New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP37625CAS No. ：1092453-15-0Purity：98%

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CAS No.	1092453-15-0	Cat. No.	BCP37625
Name	AZD-8529
Synonyms	AZD8529; AZD 8529;
SMILES	CC1=CC(=CC2=C1C(=O)N(C2)CC3=CC=C(C=C3)OC(F)(F)F)C4=NC(=NO4)CN5CCNCC5
Chemical Name
Formula	C24H24F3N5O3	M. Wt	487.47
Purity	98%	Storage	Store at 4-8°C
Description	AZD-8529 is a a positive allosteric modulator at the mGluR2 receptor. AZD8529 decreases Nicotine Self-Administration and Relapse in Squirrel Monkeys. AZD8529 potentiated agonist-induced activation of mGluR2 in the membrane-binding assay and in primate cortex, hippocampus, and striatum. In monkeys, AZD8529 decreased nicotine self-administration at doses (.3-3 mg/kg) that did not affect food self-administration. AZD8529 also reduced nicotine priming- and cue-induced reinstatement of nicotine seeking after extinction of the drug-reinforced responding. In rats, AZD8529 decreased nicotine-induced accumbens dopamine release. The positive allosteric modulators of metabotropic glutamate receptor 2 should be considered for relapse prevention.