GNE-140 racemic

  • Chemical Properties
CAS No. 1809794-70-4 Cat. No. BCP37998
Name GNE-140 racemic
Synonyms GNE140 racemic;GNE 140 racemic;
Formula C25H23ClN2O3S2 M. Wt 499.04
  • Biological Activity
Description GNE-140 racemic is a novel potent lactate dehydrogenase (LDHA) inhibitor. In MIA PaCa-2 human pancreatic cells, LDHA inhibition rapidly affected global metabolism, although cell death only occurred after 2 d of continuous LDHA inhibition. Pancreatic cell lines that utilize oxidative phosphorylation (OXPHOS) rather than glycolysis were inherently resistant to GNE-140, but could be resensitized to GNE-140 with the OXPHOS inhibitor phenformin. Acquired resistance to GNE-140 was driven by activation of the AMPK-mTOR-S6K signaling pathway, which led to increased OXPHOS, and inhibitors targeting this pathway could prevent resistance.

Structure

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