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GNE-140 racemic Chemical Structure

GNE-140 racemic

Data Sheet For research use only. Not for human use.
Cat. No. :BCP37998CAS No. :1809794-70-4Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1809794-70-4 Cat. No. BCP37998
Name GNE-140 racemic
Synonyms GNE140 racemic;GNE 140 racemic;
SMILES C1COCCN1C2=CC=C(C=C2)C3(CC(=C(C(=O)N3)SC4=CC=CC=C4Cl)O)C5=CSC=C5
Chemical Name
Formula C25H23ClN2O3S2 M. Wt 499.04
Purity 98% Storage Store at 4-8°C
Description GNE-140 racemic is a novel potent lactate dehydrogenase (LDHA) inhibitor. In MIA PaCa-2 human pancreatic cells, LDHA inhibition rapidly affected global metabolism, although cell death only occurred after 2 d of continuous LDHA inhibition. Pancreatic cell lines that utilize oxidative phosphorylation (OXPHOS) rather than glycolysis were inherently resistant to GNE-140, but could be resensitized to GNE-140 with the OXPHOS inhibitor phenformin. Acquired resistance to GNE-140 was driven by activation of the AMPK-mTOR-S6K signaling pathway, which led to increased OXPHOS, and inhibitors targeting this pathway could prevent resistance.
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