奥莫替尼双盐酸盐
| CAS号 | 1842366-97-5 | 货号 | BCP38296 |
| 中文名 | 奥莫替尼双盐酸盐 | ||
| 英文名 | Olmutinib dihydrochloride | ||
| 中文别名 | |||
| 英文别名 | BI-1482694 CL2; BI1482694 CL2; BI 1482694 CL2; | ||
| 分子式 | C26H28Cl2N6O2S | 分子量 | 559.51 |
| 生物活性 | Olmutinib is a novel third-generation epidermal growth factor receptor (EGFR) mutation-specific tyrosine kinase inhibitor, used in the treatment of T790M mutation positive non-small cell lung cancer. Olmutinib covalently binds a cysteine residue near the kinase domain of mutant EGFRs to prevent phosphorylation of the receptor. EGFRs are frequently over-expressed in lung cancer and contribute to activation of the phosphoinositide 3-kinase and mitogen-activated protein kinase pathways which both promote cell survival and proliferation. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | BTK | ||
结构式
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