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CAS号 | 1842366-97-5 | 货号 | BCP38296 |
中文名 | 奥莫替尼双盐酸盐 | ||
英文名 | Olmutinib dihydrochloride | ||
中文别名 | |||
英文别名 | BI-1482694 CL2; BI1482694 CL2; BI 1482694 CL2; | ||
SMILES | CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC4=C(C(=N3)OC5=CC=CC(=C5)NC(=O)C=C)SC=C4.Cl.Cl | ||
化学名称 | |||
分子式 | C26H28Cl2N6O2S | 分子量 | 559.51 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Olmutinib is a novel third-generation epidermal growth factor receptor (EGFR) mutation-specific tyrosine kinase inhibitor, used in the treatment of T790M mutation positive non-small cell lung cancer. Olmutinib covalently binds a cysteine residue near the kinase domain of mutant EGFRs to prevent phosphorylation of the receptor. EGFRs are frequently over-expressed in lung cancer and contribute to activation of the phosphoinositide 3-kinase and mitogen-activated protein kinase pathways which both promote cell survival and proliferation. |
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