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Olmutinib dihydrochloride 结构式

奥莫替尼双盐酸盐

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货号 :BCP38296CAS号 :1842366-97-5纯度:98%
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  • 基本信息与产品描述
CAS号 1842366-97-5 货号 BCP38296
中文名 奥莫替尼双盐酸盐
英文名 Olmutinib dihydrochloride
中文别名
英文别名 BI-1482694 CL2; BI1482694 CL2; BI 1482694 CL2;
SMILES CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC4=C(C(=N3)OC5=CC=CC(=C5)NC(=O)C=C)SC=C4.Cl.Cl
化学名称
分子式 C26H28Cl2N6O2S 分子量 559.51
纯度 98% 配送 惯例下常温包邮
产品描述 Olmutinib is a novel third-generation epidermal growth factor receptor (EGFR) mutation-specific tyrosine kinase inhibitor, used in the treatment of T790M mutation positive non-small cell lung cancer. Olmutinib covalently binds a cysteine residue near the kinase domain of mutant EGFRs to prevent phosphorylation of the receptor. EGFRs are frequently over-expressed in lung cancer and contribute to activation of the phosphoinositide 3-kinase and mitogen-activated protein kinase pathways which both promote cell survival and proliferation.
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