MK-7145
| CAS号 | 1255204-84-2 | 货号 | BCP38355 |
| 中文名 | MK-7145 | ||
| 英文名 | MK-7145 | ||
| 中文别名 | |||
| 英文别名 | MK 7145; MK7145; | ||
| 分子式 | C26H30N2O6 | 分子量 | 466.53 |
| 生物活性 | MK-7145 is a potent, selective and orally active ROMK inhibitor for the treatment of hypertension and heart failure. MK-7145 is selective against other cardiac ion channels such as Cav1.2 and Nav1.5 (IC50 > 30 μM). MK-7145 was not a potent reversible inhibitor of human CYP3A4, CYP2C9, or CYP2D6 (IC50 > 50μM) and was not a time-dependent inhibitor of CYP3A4 at 10and 50 μM. MK-7145 caused dose-dependent lowering of blood pressure in a subchronic SHR model. MK-7145 is the first small molecule ROMK inhibitor to enter clinical development. | ||
| 信号通路 | Ion Channel/Membrane Transporter | ||
| 靶 点 | Potassium Channel | ||
结构式
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