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| CAS号 | 1255204-84-2 | 货号 | BCP38355 |
| 中文名 | MK-7145 | ||
| 英文名 | MK-7145 | ||
| 中文别名 | |||
| 英文别名 | MK 7145; MK7145; | ||
| SMILES | CC1=C(C=CC2=C1COC2=O)C(CN3CCN(CC3)CC(C4=C(C5=C(C=C4)C(=O)OC5)C)O)O | ||
| 化学名称 | |||
| 分子式 | C26H30N2O6 | 分子量 | 466.53 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | MK-7145 is a potent, selective and orally active ROMK inhibitor for the treatment of hypertension and heart failure. MK-7145 is selective against other cardiac ion channels such as Cav1.2 and Nav1.5 (IC50 > 30 μM). MK-7145 was not a potent reversible inhibitor of human CYP3A4, CYP2C9, or CYP2D6 (IC50 > 50μM) and was not a time-dependent inhibitor of CYP3A4 at 10and 50 μM. MK-7145 caused dose-dependent lowering of blood pressure in a subchronic SHR model. MK-7145 is the first small molecule ROMK inhibitor to enter clinical development. | ||
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