PXS5505 HCl
| CAS号 | 2409964-23-2 | 货号 | BCP39659 |
| 中文名 | PXS5505 HCl | ||
| 英文名 | PXS5505 HCl | ||
| 中文别名 | |||
| 英文别名 | LOX-IN-3 dihydrochloride;PXS-5505 HCl;PXS 5505 HCl; | ||
| 分子式 | C13H15Cl2FN2O2S | 分子量 | 353.23 |
| 生物活性 | LOX-IN-3 dihydrochloride is an orally active lysyl oxidase (LOX) inhibitor. LOX-IN-3 dihydrochloride can be used for fibrosis, cancer and angiogenesis research.PXS-5505 is a Pan-Lysyl Oxidase Inhibitor that has been found to ameliorate multiple-organ fibrosis by inhibiting collagen crosslinks in rodent models in systemic sclerosis. PXS-5505 inhibited lysyl oxidase activity in the skin and LOXL2 activity in the lung. PXS-5505 exhibited anti-fibrotic effects in the SSc skin mouse model, reducing dermal thickness and α-smooth muscle actin. Similarly, in the bleomycin-induced mouse lung model, PXS-5505 reduced pulmonary fibrosis toward normal levels, mediated by its ability to normalise collagen/elastin crosslink formation. PXS-5505 also reduced fibrotic extent in models of the ischaemia-reperfusion heart, the unilateral ureteral obstruction kidney, and the CCl4-induced fibrotic liver. | ||
| 信号通路 | Protease/Metabolic Enzyme Neuro Signaling Pathway | ||
| 靶 点 | Monoamine Oxidase Lipoxygenase | ||
结构式
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