PXS5505 HCl 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP39659CAS号：2409964-23-2纯度：98%

规格	价格(CNY)	是否现货	购买咨询
5.00 mg	￥2500.00	In-stock	购买咨询
10.00 mg	￥4500.00	In-stock	购买咨询
25.00 mg	￥8500.00	In-stock	购买咨询
50.00 mg	￥12500.00	In-stock	购买咨询

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CAS号	2409964-23-2	货号	BCP39659
中文名	PXS5505 HCl
英文名	PXS5505 HCl
中文别名
英文别名	LOX-IN-3 dihydrochloride;PXS-5505 HCl;PXS 5505 HCl;
SMILES	C1=CC2=C(C(=C1)S(=O)(=O)CC(=CCN)F)N=CC=C2.Cl.Cl
化学名称
分子式	C13H15Cl2FN2O2S	分子量	353.23
纯度	98%	配送	惯例下常温包邮
产品描述	LOX-IN-3 dihydrochloride is an orally active lysyl oxidase (LOX) inhibitor. LOX-IN-3 dihydrochloride can be used for fibrosis, cancer and angiogenesis research.PXS-5505 is a Pan-Lysyl Oxidase Inhibitor that has been found to ameliorate multiple-organ fibrosis by inhibiting collagen crosslinks in rodent models in systemic sclerosis. PXS-5505 inhibited lysyl oxidase activity in the skin and LOXL2 activity in the lung. PXS-5505 exhibited anti-fibrotic effects in the SSc skin mouse model, reducing dermal thickness and α-smooth muscle actin. Similarly, in the bleomycin-induced mouse lung model, PXS-5505 reduced pulmonary fibrosis toward normal levels, mediated by its ability to normalise collagen/elastin crosslink formation. PXS-5505 also reduced fibrotic extent in models of the ischaemia-reperfusion heart, the unilateral ureteral obstruction kidney, and the CCl4-induced fibrotic liver.