VU 0409551
| CAS No. | 1363281-27-9 | Cat. No. | BCP39846 |
| Name | VU 0409551 | ||
| Synonyms | VU0409551; VU-0409551; JNJ-46778212; JNJ 46778212; JNJ46778212; | ||
| Formula | C20H17FN2O3 | M. Wt | 352.36 |
| Description | VU0409551 is orally bioavailable metabotropic glutamate receptor subtype 5 (mGlu5) positive allosteric modulators (PAMs). VU0409551 exhibits distinct stimulus bias and selectively potentiates mGlu5 coupling to Gαq-mediated signaling but not mGlu5 modulation of NMDAR currents or NMDAR-dependent synaptic plasticity in the rat hippocampus. On the basis of its robust in vitro potency and in vivo efficacy in multiple preclinical models of multiple domains of schizophrenia, coupled with a good DMPK profile and an acceptable therapeutic window, VU0409551/JNJ-46778212 was selected as a candidate for further development. | ||
| Pathways | Neuro Signaling Pathway GPCR/G Protein | ||
| Targets | mGluR | ||
Structure
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