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VU 0409551 Chemical Structure

VU 0409551

Data Sheet For research use only. Not for human use.
Cat. No. :BCP39846CAS No. :1363281-27-9Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1363281-27-9 Cat. No. BCP39846
Name VU 0409551
Synonyms VU0409551; VU-0409551; JNJ-46778212; JNJ 46778212; JNJ46778212;
SMILES C1CN(CC2=C1N=C(O2)COC3=CC=CC=C3)C(=O)C4=CC=C(C=C4)F
Chemical Name
Formula C20H17FN2O3 M. Wt 352.36
Purity 98% Storage Store at 4-8°C
Description VU0409551 is orally bioavailable metabotropic glutamate receptor subtype 5 (mGlu5) positive allosteric modulators (PAMs). VU0409551 exhibits distinct stimulus bias and selectively potentiates mGlu5 coupling to Gαq-mediated signaling but not mGlu5 modulation of NMDAR currents or NMDAR-dependent synaptic plasticity in the rat hippocampus. On the basis of its robust in vitro potency and in vivo efficacy in multiple preclinical models of multiple domains of schizophrenia, coupled with a good DMPK profile and an acceptable therapeutic window, VU0409551/JNJ-46778212 was selected as a candidate for further development.
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