VU 0409551
  • 化学数据
CAS号 1363281-27-9 货号 BCP39846
中文名 VU 0409551
英文名 VU 0409551
中文别名
英文别名 VU0409551; VU-0409551; JNJ-46778212; JNJ 46778212; JNJ46778212;
分子式 C20H17FN2O3 分子量 352.36
  • 用途
生物活性 VU0409551 is orally bioavailable metabotropic glutamate receptor subtype 5 (mGlu5) positive allosteric modulators (PAMs). VU0409551 exhibits distinct stimulus bias and selectively potentiates mGlu5 coupling to Gαq-mediated signaling but not mGlu5 modulation of NMDAR currents or NMDAR-dependent synaptic plasticity in the rat hippocampus. On the basis of its robust in vitro potency and in vivo efficacy in multiple preclinical models of multiple domains of schizophrenia, coupled with a good DMPK profile and an acceptable therapeutic window, VU0409551/JNJ-46778212 was selected as a candidate for further development.
信号通路 Neuro Signaling Pathway GPCR/G Protein 
靶 点 mGluR 

结构式

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