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| CAS号 | 1363281-27-9 | 货号 | BCP39846 |
| 中文名 | VU 0409551 | ||
| 英文名 | VU 0409551 | ||
| 中文别名 | |||
| 英文别名 | VU0409551; VU-0409551; JNJ-46778212; JNJ 46778212; JNJ46778212; | ||
| SMILES | C1CN(CC2=C1N=C(O2)COC3=CC=CC=C3)C(=O)C4=CC=C(C=C4)F | ||
| 化学名称 | |||
| 分子式 | C20H17FN2O3 | 分子量 | 352.36 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | VU0409551 is orally bioavailable metabotropic glutamate receptor subtype 5 (mGlu5) positive allosteric modulators (PAMs). VU0409551 exhibits distinct stimulus bias and selectively potentiates mGlu5 coupling to Gαq-mediated signaling but not mGlu5 modulation of NMDAR currents or NMDAR-dependent synaptic plasticity in the rat hippocampus. On the basis of its robust in vitro potency and in vivo efficacy in multiple preclinical models of multiple domains of schizophrenia, coupled with a good DMPK profile and an acceptable therapeutic window, VU0409551/JNJ-46778212 was selected as a candidate for further development. | ||
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