LY487379
| CAS No. | 353231-17-1 | Cat. No. | BCP39937 |
| Name | LY487379 | ||
| Synonyms | LY 487379;LY-487379; | ||
| Formula | C21H19F3N2O4S | M. Wt | 452.45 |
| Description | LY-487379 is a potent, selective positive allosteric modulator of mGluR2 (EC50=0.27 uM) without activity at mGluR3; shows no intrinsic agonist or antagonist activity at hmGluR2, markedly potentiates glutamate-stimulated [35S]GTPgammaS binding at hmGluR2; potentiates synaptically evoked mGluR2 responses in rat hippocampal slices, modulates excitatory synaptic transmission in the rat globus pallidus. | ||
| Pathways | Neuro Signaling Pathway GPCR/G Protein | ||
| Targets | mGluR | ||
Structure
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