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LY487379 Chemical Structure

LY487379

Data Sheet For research use only. Not for human use.
Cat. No. :BCP39937CAS No. :353231-17-1Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 353231-17-1 Cat. No. BCP39937
Name LY487379
Synonyms LY 487379;LY-487379;
SMILES COC1=CC=CC=C1OC2=CC=C(C=C2)N(CC3=CN=CC=C3)S(=O)(=O)CC(F)(F)F
Chemical Name
Formula C21H19F3N2O4S M. Wt 452.45
Purity 98% Storage Store at 4-8°C
Description LY-487379 is a potent, selective positive allosteric modulator of mGluR2 (EC50=0.27 uM) without activity at mGluR3; shows no intrinsic agonist or antagonist activity at hmGluR2, markedly potentiates glutamate-stimulated [35S]GTPgammaS binding at hmGluR2; potentiates synaptically evoked mGluR2 responses in rat hippocampal slices, modulates excitatory synaptic transmission in the rat globus pallidus.
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