STM2457
| CAS号 | 2499663-01-1 | 货号 | BCP40216 |
| 中文名 | STM2457 | ||
| 英文名 | STM2457 | ||
| 中文别名 | |||
| 英文别名 | STM-2457; STM 2457; | ||
| 分子式 | C25H28N6O2 | 分子量 | 444.54 |
| 生物活性 | STM2457 is a highly potent and selective first-in-class catalytic inhibitor of METTL3. Treatment of tumours with STM2457 leads to reduced AML growth and an increase in differentiation and apoptosis. These cellular effects are accompanied by selective reduction of m6A levels on known leukaemogenic mRNAs and a decrease in their expression consistent with a translational defect. Pharmacological inhibition of METTL3 in vivo leads to impaired engraftment and prolonged survival in various mouse models of AML, specifically targeting key stem cell subpopulations of AML. | ||
| 信号通路 | Others Pathway | ||
| 靶 点 | Others | ||
结构式
本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
不同批次的产品详情请咨询我们的客服：
- 全国免费电话：400-099-8200
- 在线客服:
瀚香生物（Biochempartner) 的所有产品和服务仅用于科学研究，禁止用于人体和治疗！