STM2457 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP40216CAS号：2499663-01-1纯度：98%

规格	价格(CNY)	是否现货	购买咨询
25.00 mg	￥4500.00	In-stock	购买咨询
50.00 mg	￥7500.00	In-stock	购买咨询
100.00 mg	￥1200.00	In-stock	购买咨询

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CAS号	2499663-01-1	货号	BCP40216
中文名	STM2457
英文名	STM2457
中文别名
英文别名	STM-2457; STM 2457;
SMILES	C1=CC=CC2=NC(C(=O)NCC3N=C4C=CC(CNCC5CCCCC5)=CN4C=3)=CC(=O)N12
化学名称
分子式	C25H28N6O2	分子量	444.54
纯度	98%	配送	惯例下常温包邮
产品描述	STM2457 is a highly potent and selective first-in-class catalytic inhibitor of METTL3. Treatment of tumours with STM2457 leads to reduced AML growth and an increase in differentiation and apoptosis. These cellular effects are accompanied by selective reduction of m6A levels on known leukaemogenic mRNAs and a decrease in their expression consistent with a translational defect. Pharmacological inhibition of METTL3 in vivo leads to impaired engraftment and prolonged survival in various mouse models of AML, specifically targeting key stem cell subpopulations of AML.