HBX19818
| CAS号 | 1426944-49-1 | 货号 | BCP40268 |
| 中文名 | HBX19818 | ||
| 英文名 | HBX19818 | ||
| 中文别名 | |||
| 英文别名 | HBX-19818; HBX 19818; | ||
| 分子式 | C25H28ClN3O | 分子量 | 421.96 |
| 生物活性 | HBX19818 exhibited a dose-dependent effect on USP7 activity. HBX 19,818 efficiently blocked labeling of USP7 but not that of USP8, USP5, USP10, CYLD, or UCH-L3, showing this compound's specificity for USP7 over a panel of active DUBs under physiological conditions proved to be active in cells, as it almost completely inhibited USP7 labeling at 25 mM. MS/MS spectrum revealed that HBX 19,818 is attached to Cys315. Based on UV chromatogram (l = 332 nm) peak areas, HBX 19,818 partially reverses the deubiquitination of Mdm2 by USP7 in HEK293 cells, confirming that HBX 19,818 inhibits a biological activity of USP7 in living cells. HBX 19,818 has additional off-target, p53-independent proapoptotic effects. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | DUB | ||
结构式
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