HBX19818 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP40268CAS号：1426944-49-1纯度：98%

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CAS号	1426944-49-1	货号	BCP40268
中文名	HBX19818
英文名	HBX19818
中文别名
英文别名	HBX-19818; HBX 19818;
SMILES	CN(CCCNC(=O)C1=CC2=C(C=C1)N=C3CCCCC3=C2Cl)CC4=CC=CC=C4
化学名称
分子式	C25H28ClN3O	分子量	421.96
纯度	98%	配送	惯例下常温包邮
产品描述	HBX19818 exhibited a dose-dependent effect on USP7 activity. HBX 19,818 efficiently blocked labeling of USP7 but not that of USP8, USP5, USP10, CYLD, or UCH-L3, showing this compound's specificity for USP7 over a panel of active DUBs under physiological conditions proved to be active in cells, as it almost completely inhibited USP7 labeling at 25 mM. MS/MS spectrum revealed that HBX 19,818 is attached to Cys315. Based on UV chromatogram (l = 332 nm) peak areas, HBX 19,818 partially reverses the deubiquitination of Mdm2 by USP7 in HEK293 cells, confirming that HBX 19,818 inhibits a biological activity of USP7 in living cells. HBX 19,818 has additional off-target, p53-independent proapoptotic effects.