SI-109
| CAS No. | 2429877-30-3 | Cat. No. | BCP40461 |
| Name | SI-109 | ||
| Synonyms | SI109;SI 109; | ||
| Formula | C40H44F2N7O9P | M. Wt | 835.79 |
| Description | SI-109 is a potent STAT3 SH2 domain inhibitor (Ki=9 nM) with antitumor activity. SI-109 effectively inhibits the transcriptional activity of STAT3 (IC50=3 μM). SI-109 and an analog of CRBN ligand lenalidomide have been used to design PROTAC STAT3 degrader SD-36. | ||
| Pathways | Jak/Stat Pathway Wnt/Stem Cell | ||
| Targets | Stat | ||
Structure
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