SI-109 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 2429877-30-3 | Cat. No. | BCP40461 |
| Name | SI-109 | ||
| Synonyms | SI109;SI 109; | ||
| SMILES | O=C([C@@H](NC([C@@H]1CC[C@H](CCN(C(C)=O)C[C@@H]2NC(C3=CC(C=C(C(F)(P(O)(O)=O)F)C=C4)=C4N3)=O)N1C2=O)=O)CCC(N)=O)NC(C5=CC=CC=C5)C6=CC=CC=C6 | ||
| Chemical Name | |||
| Formula | C40H44F2N7O9P | M. Wt | 835.79 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | SI-109 is a potent STAT3 SH2 domain inhibitor (Ki=9 nM) with antitumor activity. SI-109 effectively inhibits the transcriptional activity of STAT3 (IC50=3 μM). SI-109 and an analog of CRBN ligand lenalidomide have been used to design PROTAC STAT3 degrader SD-36. | ||
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