ON1231320
| CAS号 | 1312471-39-8 | 货号 | BCP40722 |
| 中文名 | ON1231320 | ||
| 英文名 | ON1231320 | ||
| 中文别名 | |||
| 英文别名 | ON-1231320;ON 1231320; | ||
| 分子式 | C22H15F2N5O3S | 分子量 | 467.45 |
| 生物活性 | ON1231320 is a Polo-like kinase 2 (PLK2) inhibitor. In vitro testing revealed that ON1231320 is a selective inhibitor of PLK2 with no inhibitory activity against PLK1, PLK3 and PLK4. The cytotoxic effect of the drug is mediated by apoptosis as evidenced by the induction of Caspase 3/7 activity and by the cleavage of PARP in a dose dependent manner. ON1231320 affects cell cycle progression by blocking tumor cells in the G2/M phase however it does not affect normal human fibroblasts. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | PLK | ||
结构式
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