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ON1231320 结构式

ON1231320

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货号 :BCP40722CAS号 :1312471-39-8纯度:98%
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  • 基本信息与产品描述
CAS号 1312471-39-8 货号 BCP40722
中文名 ON1231320
英文名 ON1231320
中文别名
英文别名 ON-1231320;ON 1231320;
SMILES CN1C2=NC(=NC=C2C=C(C1=O)S(=O)(=O)C3=C(C=C(C=C3)F)F)NC4=CC5=C(C=C4)NC=C5
化学名称
分子式 C22H15F2N5O3S 分子量 467.45
纯度 98% 配送 惯例下常温包邮
产品描述 ON1231320 is a Polo-like kinase 2 (PLK2) inhibitor. In vitro testing revealed that ON1231320 is a selective inhibitor of PLK2 with no inhibitory activity against PLK1, PLK3 and PLK4. The cytotoxic effect of the drug is mediated by apoptosis as evidenced by the induction of Caspase 3/7 activity and by the cleavage of PARP in a dose dependent manner. ON1231320 affects cell cycle progression by blocking tumor cells in the G2/M phase however it does not affect normal human fibroblasts.
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