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CAS号 | 1312471-39-8 | 货号 | BCP40722 |
中文名 | ON1231320 | ||
英文名 | ON1231320 | ||
中文别名 | |||
英文别名 | ON-1231320;ON 1231320; | ||
SMILES | CN1C2=NC(=NC=C2C=C(C1=O)S(=O)(=O)C3=C(C=C(C=C3)F)F)NC4=CC5=C(C=C4)NC=C5 | ||
化学名称 | |||
分子式 | C22H15F2N5O3S | 分子量 | 467.45 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | ON1231320 is a Polo-like kinase 2 (PLK2) inhibitor. In vitro testing revealed that ON1231320 is a selective inhibitor of PLK2 with no inhibitory activity against PLK1, PLK3 and PLK4. The cytotoxic effect of the drug is mediated by apoptosis as evidenced by the induction of Caspase 3/7 activity and by the cleavage of PARP in a dose dependent manner. ON1231320 affects cell cycle progression by blocking tumor cells in the G2/M phase however it does not affect normal human fibroblasts. |
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