IWP-O1
| CAS No. | 2074607-48-8 | Cat. No. | BCP41115 |
| Name | IWP-O1 | ||
| Synonyms | IWPO1; IWP O1; | ||
| Formula | C26H20N6O | M. Wt | 432.48 |
| Description | IWP-O1 is highly potent Porcn inhibitor, The acyltransferase Porcupine (Porcn) is essential for the secretion of Wnt proteins which contribute to embryonic development, tissue regeneration, and tumorigenesis. IWP-O1 has an EC50 value of 80pM in a cultured cell reporter assay of Wnt signaling. Additionally, IWP-O1 has significantly improved metabolic stability over our previously reported Porcn inhibitors. | ||
| Pathways | Wnt/Stem Cell | ||
| Targets | Wnt | ||
Structure
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