Decanoyl-arg-val-lys-arg-chloromethylketone
| CAS No. | 150113-99-8 | Cat. No. | BCP41990 |
| Name | Decanoyl-arg-val-lys-arg-chloromethylketone | ||
| Synonyms | Dec-RVKR-CMK;Decanoyl-RVKR-CMK;Furin Inhibitor I; | ||
| Formula | C34H66ClN11O5 | M. Wt | 744.41 |
| Description | Decanoyl-RVKR-CMK is a subtilisin/Kex2p-like proprotein convertase inhibitor; blocks activity of all seven convertases (PC1, PC2, PC4, PACE4, PC5, PC7 and furin). Abolishes proET-1 processing in endothelial cells; inhibits regulated secretion of the neuronal polypeptide VGF in PC12 cells. Inhibits cleavage of glycoprotein B of human cytomegalovirus. Also inhibits cleavage of SARS-CoV-2 spike protein by furin and blocks viral cell entry (IC50 = 57 nM in plaque reduction assay). | ||
| Pathways | Microbiology/Virology | ||
| Targets | SARS CoV | ||
Structure
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