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Decanoyl-arg-val-lys-arg-chloromethylketone Chemical Structure

Decanoyl-arg-val-lys-arg-chloromethylketone

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP41990CAS No. ：150113-99-8Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 150113-99-8 Cat. No. BCP41990
Name Decanoyl-arg-val-lys-arg-chloromethylketone
Synonyms Dec-RVKR-CMK;Decanoyl-RVKR-CMK;Furin Inhibitor I;
SMILES CCCCCCCCCC(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CCCN=C(N)N)C(=O)CCl
Chemical Name
Formula C34H66ClN11O5 M. Wt 744.41
Purity 98% Storage Store at 4-8°C
Description Decanoyl-RVKR-CMK is a subtilisin/Kex2p-like proprotein convertase inhibitor; blocks activity of all seven convertases (PC1, PC2, PC4, PACE4, PC5, PC7 and furin). Abolishes proET-1 processing in endothelial cells; inhibits regulated secretion of the neuronal polypeptide VGF in PC12 cells. Inhibits cleavage of glycoprotein B of human cytomegalovirus. Also inhibits cleavage of SARS-CoV-2 spike protein by furin and blocks viral cell entry (IC50 = 57 nM in plaque reduction assay).
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