NBI-31772
| CAS No. | 374620-70-9 | Cat. No. | BCP42327 |
| Name | NBI-31772 | ||
| Synonyms | NBI 31772; NBI31772; | ||
| Formula | C17H11NO7 | M. Wt | 341.27 |
| Description | NBI 31772 is a high affinity insulin-like growth factor-1 binding protein (IGFBP) inhibitor (Ki values are 1 - 24 nM for all six human subtypes). Displaces insulin-like growth factor-1 (IGF-1) from the IGF-1:IGFBP complex and suppresses IGF1-induced proliferation of 3T3 fibroblasts. Also increases cardiomyocyte proliferation in vivo. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | Insulin Receptor | ||
Structure
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