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CAS No. | 374620-70-9 | Cat. No. | BCP42327 |
Name | NBI-31772 | ||
Synonyms | NBI 31772; NBI31772; | ||
SMILES | C1=CC(=C(C=C1C(=O)C2=NC(=CC3=CC(=C(C=C32)O)O)C(=O)O)O)O | ||
Chemical Name | |||
Formula | C17H11NO7 | M. Wt | 341.27 |
Purity | 98% | Storage | Store at 4-8°C |
Description | NBI 31772 is a high affinity insulin-like growth factor-1 binding protein (IGFBP) inhibitor (Ki values are 1 - 24 nM for all six human subtypes). Displaces insulin-like growth factor-1 (IGF-1) from the IGF-1:IGFBP complex and suppresses IGF1-induced proliferation of 3T3 fibroblasts. Also increases cardiomyocyte proliferation in vivo. |
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