DDO-5936
| CAS No. | 2355377-13-6 | Cat. No. | BCP42338 |
| Name | DDO-5936 | ||
| Synonyms | DDO 5936; DDO5936; | ||
| Formula | C25H29N5O4S | M. Wt | 495.59 |
| Description | DDO-5936 is a potent PPI inhibitor targeting Hsp90-Cdc37 protein-protein interaction (PPI) as Orally Active Inhibitors for the Treatment of Colorectal Cancer. DDO-5936 disrupted the Hsp90-Cdc37 PPI both in vitro and in vivo via binding to a previously unknown site on Hsp90 involving Glu47, one of the binding determinants for the Hsp90-Cdc37 PPI, leading to selective down-regulation of Hsp90 kinase clients in HCT116 cells. In addition, inhibition of Hsp90-Cdc37 complex formation by DDO-5936 resulted in a remarkable cyclin-dependent kinase 4 decrease and consequent inhibition of cell proliferation through Cdc37-dependent cell cycle arrest. | ||
| Pathways | Protease/Metabolic Enzyme Cell Cycle/DNA Damage | ||
| Targets | HSP | ||
Structure
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