DDO-5936 New
Data Sheet
For research use only. Not for human use.
Get Quotation Now* Required Fields.
Please complete the form below and you will get the price list in 1 minute.
* Required Fields.
Please complete the form below and we will contact you shortly.
* Required Fields.
Please complete the form below and we will contact you shortly.
| CAS No. | 2355377-13-6 | Cat. No. | BCP42338 |
| Name | DDO-5936 | ||
| Synonyms | DDO 5936; DDO5936; | ||
| SMILES | CC1=CC(=C(C(=C1)C)S(=O)(=O)N(CC(=O)O)C2=CC=C(C=C2)NC3=NC(=NC=C3)N4CCCC4)C | ||
| Chemical Name | |||
| Formula | C25H29N5O4S | M. Wt | 495.59 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | DDO-5936 is a potent PPI inhibitor targeting Hsp90-Cdc37 protein-protein interaction (PPI) as Orally Active Inhibitors for the Treatment of Colorectal Cancer. DDO-5936 disrupted the Hsp90-Cdc37 PPI both in vitro and in vivo via binding to a previously unknown site on Hsp90 involving Glu47, one of the binding determinants for the Hsp90-Cdc37 PPI, leading to selective down-regulation of Hsp90 kinase clients in HCT116 cells. In addition, inhibition of Hsp90-Cdc37 complex formation by DDO-5936 resulted in a remarkable cyclin-dependent kinase 4 decrease and consequent inhibition of cell proliferation through Cdc37-dependent cell cycle arrest. | ||
Recommend Products
More >
-
-
-
-
HSP27 inhibitor J2
Cat. No.：BCP46015
No.：2133499-85-9
Product Details -
-
Shepherdin
Cat. No.：BCP42633
No.：861224-28-4
Product Details -
-
-
Retaspimycin hydrochloride
Cat. No.：BCP36508
No.：857402-63-2
Product Details -
-
-
3-Methyltoxoflavin
Cat. No.：BCP30844
No.：32502-62-8
Product Details -
-
TRC 051384
Cat. No.：BCP29281
No.：867164-40-7
Product Details -
-
-
-
Debio 0932
Cat. No.：BCP27980
No.：1061318-81-7
Product Details -
Apatorsen Sodium
Cat. No.：BCP27709
No.：915443-09-3
Product Details -
Alvespimycin HCl
Cat. No.：BCP22705
No.：467214-21-7
Product Details
Tags:DDO-5936 supplier,DDO-5936 purchase,DDO-5936 manufacturer,DDO-5936 distributor,DDO-5936 cost,DDO-5936 buy,DDO-5936 for sale