JH-X-119-01
| CAS No. | 2227368-54-7 | Cat. No. | BCP42501 |
| Name | JH-X-119-01 | ||
| Synonyms | JH-X119-01; JH-X 119-01; JH-X-11901; JH-X11901; JH-X 11901; JHX-11901; JHX11901; JHX 11901; | ||
| Formula | C25H20N6O3 | M. Wt | 452.46 |
| Description | Jh-X-119-01 is a novel potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 irreversibly labels IRAK1 at C302. This compound exhibited cytotoxic activity at single digit micromolar concentrations in a panel of WM, DLBCL, and lymphoma cell lines expressing MYD88. Cotreatment of JH-X-119-01 with the BTK inhibitor ibrutinib resulted in synergistic killing effects in these systems. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | IRAK | ||
Structure
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