JH-X-119-01 New
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| CAS No. | 2227368-54-7 | Cat. No. | BCP42501 |
| Name | JH-X-119-01 | ||
| Synonyms | JH-X119-01; JH-X 119-01; JH-X-11901; JH-X11901; JH-X 11901; JHX-11901; JHX11901; JHX 11901; | ||
| SMILES | O=C(NC1=CC=C(NC(C2=CC=CC(NC(C=C)=O)=C2)=O)C=C1)C3=NC(C4=CC=NN4)=CC=C3 | ||
| Chemical Name | |||
| Formula | C25H20N6O3 | M. Wt | 452.46 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Jh-X-119-01 is a novel potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 irreversibly labels IRAK1 at C302. This compound exhibited cytotoxic activity at single digit micromolar concentrations in a panel of WM, DLBCL, and lymphoma cell lines expressing MYD88. Cotreatment of JH-X-119-01 with the BTK inhibitor ibrutinib resulted in synergistic killing effects in these systems. | ||
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