Apostatin-1
| CAS No. | 2559703-06-7 | Cat. No. | BCP42606 |
| Name | Apostatin-1 | ||
| Synonyms | Apostatin1; Apostatin 1; Apt-1; Apt1; Apt 1; | ||
| Formula | C19H27N3OS | M. Wt | 345.51 |
| Description | Apostatin-1 is a novel TRADD inhibitor.Apostatin-1 inhibits RIPK1-dependent apoptosis (RDA) with IC50 of 1.28 μM and shows no significant off-target activity on 97 kinases in KINOME scan profiling.Inhibition of TRADD by Apostatin-1 blocks apoptosis and restores cellular homeostasis by activating autophagy in cells with accumulated mutant tau, α-synuclein, or huntingtin. Treatment with Apt-1 restored proteostasis and inhibited cell death in a mouse model of proteinopathy induced by mutant tau(P301S). | ||
| Pathways | Others Pathway | ||
| Targets | Autophagy | ||
Structure
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