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Apostatin-1 Chemical Structure

Apostatin-1

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP42606CAS No. ：2559703-06-7Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 2559703-06-7 Cat. No. BCP42606
Name Apostatin-1
Synonyms Apostatin1; Apostatin 1; Apt-1; Apt1; Apt 1;
SMILES CN1CCN=C1SC(C2=CC=CC=C2)C(=O)NC3CCCCCC3
Chemical Name
Formula C19H27N3OS M. Wt 345.51
Purity 98% Storage Store at 4-8°C
Description Apostatin-1 is a novel TRADD inhibitor.Apostatin-1 inhibits RIPK1-dependent apoptosis (RDA) with IC50 of 1.28 μM and shows no significant off-target activity on 97 kinases in KINOME scan profiling.Inhibition of TRADD by Apostatin-1 blocks apoptosis and restores cellular homeostasis by activating autophagy in cells with accumulated mutant tau, α-synuclein, or huntingtin. Treatment with Apt-1 restored proteostasis and inhibited cell death in a mouse model of proteinopathy induced by mutant tau(P301S).
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