Merafloxacin
| CAS No. | 91188-00-0 | Cat. No. | BCP42636 |
| Name | Merafloxacin | ||
| Synonyms | CI 934; CI-934; CI934; | ||
| Formula | C19H23F2N3O3 | M. Wt | 379.41 |
| Description | Merafloxacin is a fluoroquinolone antibacterial, which was also identified as a −1 PRF inhibitor of SARS-CoV-2. Frameshift inhibition by merafloxacin is robust to mutations within the pseudoknot region and is similarly effective on −1 PRF of other beta coronaviruses. Importantly, frameshift inhibition by merafloxacin substantially impedes SARS-CoV-2 replication in Vero E6 cells, thereby providing the proof of principle of targeting −1 PRF as an effective antiviral strategy for SARS-CoV-2. | ||
| Pathways | Microbiology/Virology | ||
| Targets | Antibiotic SARS CoV | ||
Structure
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