Merafloxacin New
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CAS No. | 91188-00-0 | Cat. No. | BCP42636 |
Name | Merafloxacin | ||
Synonyms | CI 934; CI-934; CI934; | ||
SMILES | CCNCC1CCN(C1)C2=C(C=C3C(=C2F)N(C=C(C3=O)C(=O)O)CC)F | ||
Chemical Name | |||
Formula | C19H23F2N3O3 | M. Wt | 379.41 |
Purity | 98% | Storage | Store at 4-8°C |
Description | Merafloxacin is a fluoroquinolone antibacterial, which was also identified as a −1 PRF inhibitor of SARS-CoV-2. Frameshift inhibition by merafloxacin is robust to mutations within the pseudoknot region and is similarly effective on −1 PRF of other beta coronaviruses. Importantly, frameshift inhibition by merafloxacin substantially impedes SARS-CoV-2 replication in Vero E6 cells, thereby providing the proof of principle of targeting −1 PRF as an effective antiviral strategy for SARS-CoV-2. |
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