Pirtobrutinib
| CAS No. | 2101700-15-4 | Cat. No. | BCP42730 |
| Name | Pirtobrutinib | ||
| Synonyms | LOXO-305;LOXO 305;LOXO305;BTK inhibitor 16; | ||
| Formula | C22H21F4N5O3 | M. Wt | 479.43 |
| Description | Pirtobrutinib is an investigational, novel, selective non-covalent Bruton’s tyrosine kinase (BTK) inhibitor. LOXO-305 was designed to reversibly bind BTK, preserve activity in the presence of the acquired resistance, and avoid off-target kinases that have complicated the development of both covalent and investigational non-covalent BTK inhibitors.LOXO-305 is a highly selective, non-covalent BTKi that inhibits both wild type (WT) and C481-mutated BTK with equal low nM potency was developed. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | BTK | ||
Structure
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