Pirtobrutinib New
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| CAS No. | 2101700-15-4 | Cat. No. | BCP42730 |
| Name | Pirtobrutinib | ||
| Synonyms | LOXO-305;LOXO 305;LOXO305;BTK inhibitor 16; | ||
| SMILES | CC(C(F)(F)F)N1C(=C(C(=N1)C2=CC=C(C=C2)CNC(=O)C3=C(C=CC(=C3)F)OC)C(=O)N)N | ||
| Chemical Name | |||
| Formula | C22H21F4N5O3 | M. Wt | 479.43 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Pirtobrutinib is an investigational, novel, selective non-covalent Bruton’s tyrosine kinase (BTK) inhibitor. LOXO-305 was designed to reversibly bind BTK, preserve activity in the presence of the acquired resistance, and avoid off-target kinases that have complicated the development of both covalent and investigational non-covalent BTK inhibitors.LOXO-305 is a highly selective, non-covalent BTKi that inhibits both wild type (WT) and C481-mutated BTK with equal low nM potency was developed. | ||
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