DDR1-IN-2
| CAS No. | 1429617-90-2 | Cat. No. | BCP43189 |
| Name | DDR1-IN-2 | ||
| Synonyms | DDR1-IN-7rh; 7RH; DDR1 Inhibitor 7rh; | ||
| Formula | C30H29F3N6O | M. Wt | 546.59 |
| Description | DDR1-IN-2 is a potent and selective DDR1 inhibitor (IC50 = 6.8 nM). Exhibits selectivity for DDR1 over DDR2, Bcr-Abl and c-Kit (IC50 values are 101.4 and 355 nM and > 10 μM, respectively) and a range of other kinases. Inhibits proliferation of cancer cell lines expressing high levels of DDR1 in vitro and suppresses cancer cell invasion, adhesion and tumorigenicity. Orally bioavailable. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | DDR | ||
Structure
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