GSK3685032
| CAS号 | 2170137-61-6 | 货号 | BCP43733 |
| 中文名 | GSK3685032 | ||
| 英文名 | GSK3685032 | ||
| 中文别名 | |||
| 英文别名 | GSK-3685032;GSK 3685032; | ||
| 分子式 | C22H24N6OS | 分子量 | 420.54 |
| 生物活性 | GSK3685032, a potent first-in-class DNMT1-selective inhibitor that was shown via crystallographic studies to compete with the active-site loop of DNMT1 for penetration into hemi-methylated DNA between two CpG base pairs. GSK3685032 induces robust loss of DNA methylation, transcriptional activation and cancer cell growth inhibition in vitro. Due to improved in vivo tolerability compared with decitabine, GSK3685032 yields superior tumor regression and survival mouse models of acute myeloid leukemia. | ||
| 上下游产品 | GSK3685032TFA（GSK3685032 TFA盐） 2170140-50-6（(R)-GSK-3685032） | ||
| 信号通路 | Epigenetics | ||
| 靶 点 | DNA Methyltransferase | ||
结构式
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