NI-42
| CAS号 | 1884640-99-6 | 货号 | BCP43848 |
| 中文名 | NI-42 | ||
| 英文名 | NI-42 | ||
| 中文别名 | |||
| 英文别名 | NI 42; NI42; | ||
| 分子式 | C18H15N3O3S | 分子量 | 353.39 |
| 生物活性 | NI-42 is a potent and selective BRPF1 in inhibitor with BRPF1 IC50 = 7.9 nM; LE: 0.45; LLE: 5.6. NI-42 is suitable for cellular and in vivo studies to explore the fundamental biology of these proteins. The BRPF (bromodomain and PHD finger-containing) family are scaffolding proteins important for the recruitment of histone acetyltransferases of the MYST family to chromatin. Evaluation of the BRPF family as a potential drug target is at an early stage although there is an emerging understanding of a role in acute myeloid leukemia (AML). | ||
| 信号通路 | Epigenetics | ||
| 靶 点 | Epigenetic Reader Domain | ||
结构式
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