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Epigenetic Reader Domain

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Epigenetic Reader Domain

结构式 货号 产品名称 CAS号
PFI-4 结构式
 BCP23818 PFI-4 900305-37-5
PFI-4 is a potent and highly selective BRPF1 Bromodomain (BRPF1B) inhibitor, with an IC50 of 172 nM. PFI-4 can be used to explore the functional mechanisms of the HBO1/BRPF1 complex and to study bone loss and osteolytic malignant bone lesions.
BAZ2-ICR 结构式
 BCP23999 BAZ2-ICR 1665195-94-7
BAZ2-ICR is a potent, selective, cell active and orally active BAZ2A/B bromodomains inhibitor with IC50s of 130 nM and 180 nM, and Kds of 109 nM and 170 nM, respectively. BAZ2-ICR shows 10-15-fold selectivity for binding BAZ2A/B over CECR2 and >100-fold selectivity over all other bromodomains. BAZ2-ICR is an epigenetic chemical probe.
BMS 986158 结构式
 BCP25147 BMS 986158 1800340-40-2
BMS-986158 is an inhibitor of the bromodomain and extra-terminal (BET) proteins.
SRX3177 结构式
 BCP48567 SRX3177 2241237-51-2
SRX3177 is a novel potent triple action inhibitor, targeting BRD, PI3K, and CDK.
AU-15330 结构式
 BCP46987 AU-15330 2380274-50-8
AU-15330 is a novel, highly specific and VHL-dependent PROTAC degrader of SWI/SNF ATPase components (SMARCA2, SMARCA4 and PBRM1) that shows preferential cytotoxicity in enhancer-binding transcription factor-addicted cancers at low nanomolar concentrations.
EML 425 结构式
 BCP46797 EML 425 1675821-32-5
EML425 is a potent and selective CREB binding protein (CBP)/p300 inhibitor with IC50s of 2.9 and 1.1 μM, respectively.
CFT-8634 结构式
 BCP46564 CFT-8634 2704617-96-7
CFT-8634 is a degrader targeting BRD9 extracted from patent WO2021178920A1 compound 173.
GSK1379725A 结构式
 BCP46513 GSK1379725A 1802251-00-8
GSK1379725A is the first selective inhibitor of BPTF over Brd4.
BAZ1A-IN-1 结构式
 BCP46449 BAZ1A-IN-1 941521-45-5
BAZ1A-IN-1 is a potent inhibitor of BAZ1A (bromodomain-containing protein). BAZ1A-IN-1 shows a KD value of 0.52 μM against BAZ1A bromodomain.
M-525 结构式
 BCP46311 M-525 2173582-08-4
M-525 is a first-in-class, highly potent, irreversible small-molecule inhibitor of the menin-MLL interaction.
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