PF-06446846

  • Chemical Properties
CAS No. 1632250-49-7 Cat. No. BCP43978
Name PF-06446846
Synonyms PF 06446846; PF06446846; PF-6446846; PF 6446846; PF6446846;
Formula C22H20ClN7O M. Wt 433.89
  • Biological Activity
Description PF-06446846 is a selective orally active PCSK9 inhibitor that appears to act by causing the ribosome to stall when synthesizing PCSK9. PCSK9 binds to the LDL receptor, preventing it from removing LDL cholesterol from the blood. PF-06446846 was found to reduce plasma PCSK9 and total cholesterol levels in rats.
Related Products 1632250-50-0(PF-06446846 hydrochloride)
Pathways Protease/Metabolic Enzyme 
Targets Serine Protease 

Structure

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