PF-06446846 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1632250-49-7 | Cat. No. | BCP43978 |
| Related Products | 1632250-50-0（PF-06446846 hydrochloride） | ||
| Name | PF-06446846 | ||
| Synonyms | PF 06446846; PF06446846; PF-6446846; PF 6446846; PF6446846; | ||
| SMILES | C1CC(CNC1)N(C2=C(C=CC=N2)Cl)C(=O)C3=CC=C(C=C3)N4C5=C(C=CC=N5)N=N4 | ||
| Chemical Name | |||
| Formula | C22H20ClN7O | M. Wt | 433.89 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | PF-06446846 is a selective orally active PCSK9 inhibitor that appears to act by causing the ribosome to stall when synthesizing PCSK9. PCSK9 binds to the LDL receptor, preventing it from removing LDL cholesterol from the blood. PF-06446846 was found to reduce plasma PCSK9 and total cholesterol levels in rats. | ||
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