Bomedemstat ditosylate
| CAS号 | 1990504-72-7 | 货号 | BCP44102 |
| 中文名 | Bomedemstat ditosylate | ||
| 英文名 | Bomedemstat ditosylate | ||
| 中文别名 | |||
| 英文别名 | IMG-7289 ditosylate; IMG 7289; IMG7289; | ||
| 分子式 | C42H50FN7O8S2 | 分子量 | 864.02 |
| 生物活性 | Bomedemstat is a lysine-specific histone demethylase 1 (LSD1) inhibitor with antineoplastic activity. Bomedemstat may be useful in the treatment of acute myeloid leukaemia, myelodysplastic syndrome, and Myelofibrosis. IMG-7289 selectively inhibited proliferation and induced apoptosis of JAK2 V617F cells by concomitantly increasing expression and methylation of p53, and, independently, the pro-apoptotic factor PUMA and by decreasing the levels of its antiapoptotic antagonist BCLXL. | ||
| 上下游产品 | 1990504-34-1（Bomedemstat） | ||
| 信号通路 | Epigenetics | ||
| 靶 点 | Histone Demethylase | ||
结构式
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